The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its
historic popularity in drug design either as a pharmacophore or as a scaffold that projects …

Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

While chain‐walking stimulates wide interest in both polymerization and organic synthesis,
site‐and stereoselective control of chain‐walking on rings is still a challenging task in the …

Cyclic nucleotide phosphodiesterase 4 (PDE4) specifically hydrolyzes cyclic adenosine
monophosphate (cAMP) and plays vital roles in biological processes such as cancer …

Incorporation of heterocycles into drug molecules can enhance physical properties and
biological activity. A variety of heterocyclic groups is available to medicinal chemists, many …

Abstract Phosphodiesterase 4 (PDE4) hydrolyzes cyclic adenosine monophosphate (cAMP)
and plays a vital roles in many biological processes. PDE4 inhibitors have been widely …

Virtual small molecule libraries are valuable resources for identifying bioactive compounds
in virtual screening campaigns and improving the quality of libraries in terms of …

Esterification was used to simultaneously increase solubility and permeability of
ciprofloxacin, a biopharmaceutics classification system (BCS) class 4 drug (low solubility/low …

New multicomponent domino reactions of arylglyoxals with pyrazol-5-amines have been
established, providing selective access to unprecedented pyrazolo-fused 1, 7 …

Obesity, a global pandemic posing a growing threat to human health, necessitates the
development of effective and safe anti-obesity agents. Our previous studies highlighted the …