Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia
induced by infarction leads to profound changes in endothelial cell functions and can induce …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …

Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …