Diabetic neuropathies are the most common chronic complications of diabetes, with an
estimated lifetime prevalence exceeding 50% in people with diabetes. Among various forms …

Diabetes mellitus (DM) significantly increases the risk of heart disease, and DM-related
healthcare expenditure is predominantly for the management of cardiovascular …

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus
and no effective therapy is approved. Here, lycorine, a natural alkaloid, was identified as a …

Homeostatic regulation of adipose tissue is critical for the maintenance of energy balance
and whole-body metabolism. The peripheral nervous system provides bidirectional neural …

Neuroinflammation contributes significantly to the pathogenesis of diabetic peripheral
neuropathy (DPN). Quercetin reportedly exerts neuroprotective effects in DPN. Here, we …

Diabetic polyneuropathy (DPN) is the most common neuropathy manifested in diabetes.
Symptoms include allodynia, pain, paralysis, and ulcer formation. There is currently no …

Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus. Tight
glycaemic management focused on lowering haemoglobin A1C and increasing time in the …

Background Diabetic peripheral neuropathy (DPN) constitutes a debilitating complication
associated with diabetes. Although, the past decade has seen rapid developments in …

Highlights•The mechanism of HGWD intervention DPN was studied for the first time by
combining metabolomics and microbiomics.•HGWD can ameliorate the phenotype of …

Astragali Radix is a significant traditional Chinese medication, and has a long history of
clinical application in the treatment of diabetes mellitus (DM) and its complications. AS-IV is …