Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress
produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells …

Recent research using magnetic resonance imaging has documented changes in the adult
human brain's grey matter structure induced by alterations in experiential demands. We …

There is a strong association between late-life depression, cognitive impairment,
cerebrovascular disease, and poor cognitive outcomes, including progressive dementia …

Dementia is a common and debilitating syndrome with enormous impact on individuals and
societies. Preventing disease onset or progression would translate to public health and …

The hippocampus, a limbic structure important in learning and memory, is particularly
sensitive to chronic stress and to glucocorticoids. While glucocorticoids are essential for an …

Gastrodiae Rhizoma, also called chì jiàn (赤箭), guǐ dū yóu (鬼督郵), or tiān má (天麻) in
Chinese, is considered a top grade (上品shàng pǐn) medicine described to enter liver …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Context Most neuroimaging studies of posttraumatic stress disorder (PTSD) have focused on
potential abnormalities in the whole hippocampus, but the subfields of this structure, which …