Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis—
UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 …

DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that
is coordinated with the cellular DNA damage response, repair and recombination of the viral …

Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the
regulation of lytic and latent viral infection. Like the related proteins expressed by other …

Much of the HSV-1 life cycle is carried out in the cell nucleus, including the expression,
replication, repair, and packaging of viral genomes. Viral proteins, as well as cellular factors …

Viruses are by definition fully dependent on the cellular translation machinery, and develop
diverse mechanisms to co-opt this machinery for their own benefit. Unlike many viruses …

Production of concatemeric DNA is an essential step during HSV infection, as the packaging
machinery must recognize longer-than-unit-length concatemers; however, the mechanism …

Herpes simplex virus type 1 (HSV-1) infects over half the human population. Much of the
infectious cycle occurs in the nucleus of cells where the virus has evolved mechanisms to …

Herpesviruses utilize multiple mechanisms to redirect host proteins for use in viral processes
and to avoid recognition and repression by the host. To investigate dynamic interactions …

Background The maintenance of chromosomal integrity is an essential task of every living
organism and cellular repair mechanisms exist to guard against insults to DNA. Given the …

The herpes simplex virus 1 (HSV-1) virion DNA contains nicks and gaps, and in this study a
novel assay for estimating the size and number of gaps in virion DNA was developed …