Stress (biotic or abiotic) is an unfavourable condition for an organism including fungus. To
overcome stress, organism expresses heat‐shock proteins (Hsps) or chaperons to perform …

Paracoccidioides brasiliensis and P. lutzii are etiologic agents of paracoccidioidomycosis
(PCM), an important endemic mycosis in Latin America. During its evolution, these fungi …

Fungal transcription factor Upc2 senses ergosterol levels and regulates sterol biosynthesis
and uptake. Constitutive activation of Upc2 causes azole resistance in Candida species. We …

Paracoccidioides spp. are dimorphic fungal pathogens responsible for one of the most
relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact …

Heat-shock proteins (Hsps) are chaperones required for the maintenance of cellular
homeostasis in different fungal pathogens, playing an important role in the infectious …

Heat shock proteins (Hsps) are highly conserved biomolecules that are constitutively
expressed and generally upregulated in response to various stress conditions (biotic and …

Background Paracoccidioides is the causative agent of paracoccidioidomycosis, a systemic
mycosis endemic to Latin America. Infection is initiated by inhalation of conidia (C) or …

The pathogenic fungi C andida albicans, A spergillus fumigatus, and C ryptococcus
neoformans are an increasing cause of human mortality, especially in immunocompromised …

HSP90 is a molecular chaperone that participates in folding, stabilization, activation, and
assembly of several proteins, all of which are key regulators in cell signaling. In dimorphic …

Heat shock proteins (HSPs) are proteins whose transcription responds rapidly to
temperature shifts. They constitute a family of molecular chaperones, involved in the proper …