The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

The revelation of the anticancer properties of cisplatin has inspired research into metal
complexes for the treatment of cancer. Several second and third generation cisplatin …

Organometallic compounds are renowned for their remarkable applications in the field of
catalysis, but much less is known about their potential in chemical biology. Indeed, such …

To establish the druggability of a target, genetic validation needs to be supplemented with
pharmacological validation. Pharmacological studies, especially in the kinase field, are …

We present here some of our studies on the synthesis and behaviour of ferrocenyl selective
endocrine receptor modulators against cancer cells, particularly breast and prostate …

The importance of organometallics can be noticed by their presence in all life organisms.
The most known natural organometallic molecule is vitamin B12, a porphyrin containing a …

N 1-Hydroxy-N 8-ferrocenyloctanediamide, JAHA (7), an organometallic analogue of SAHA
containing a ferrocenyl group as a phenyl bioisostere, displays nanomolar inhibition of class …

Tyrosine Kinases are enzymes that catalyse the phosphorylation of the tyrosine residues of
their substrates and activate downstream pathways involved in cellular proliferation. Their …

Malaria, caused by several Plasmodium species, is the major life-threatening parasitic
infection worldwide. Due to the parasite resistance to quinoline based drugs, the search for …

The state of the art of preparative thin-layer chromatography (PTLC) based on the literature
published from 2007 through 2016 is reviewed. Classical capillary flow PTLC, forced flow …