The targets of currently used antibacterial agents: lessons for drug discovery

RP Lange, HH Locher, PC Wyss… - Current pharmaceutical …, 2007 - ingentaconnect.com
Based on the mode of action of antibacterial drugs currently used, targets can be defined as
distinct cellular constituents such as enzymes, enzyme substrates, RNA, DNA, and …

Daptomycin: evaluation of a high-dose treatment strategy

G Wu, T Abraham, J Rapp, F Vastey, N Saad… - International journal of …, 2011 - Elsevier
With a decreasing pipeline of novel antibiotics and increasing antibacterial resistance, the
need to optimise the current antibiotics in our armamentarium has become vitally important …

Incidence and survival in sarcoma in the United States: a focus on musculoskeletal lesions

VY Ng, TJ Scharschmidt, JL Mayerson… - Anticancer …, 2013 - ar.iiarjournals.org
Background/Aim: The purpose of this study was to analyze the incidence and survival in all
sarcomas based on year of diagnosis, anatomical site, grade, stage, and age of patient …

Antimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum

GA Birkemo, O O'sullivan, RP Ross… - Journal of Applied …, 2009 - academic.oup.com
Aims: To isolate and characterize peptides from bovine colostrum with antimicrobial activity.
Methods and Results: Three peptides were purified from fresh colostrum by a range of …

Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia

K Steinwede, O Tempelhof, K Bolte, R Maus… - The Journal of …, 2011 - journals.aai.org
The growth factor GM-CSF has an important role in pulmonary surfactant metabolism and
the regulation of antibacterial activities of lung sentinel cells. However, the potential of intra …

Determination of phenolic contents, antioxidant and antibacterial activities of strawberry tree (Arbutus unedo L.) leaf extracts

A Bouyahya, N Moussaoui, J Abrini… - British …, 2016 - science.sdpublishers.org
Aims: This study was designed to evaluate the antibacterial and antioxidant activities of
methanolic, ethanolic, ethyl acetate and n-hexanic extract from the leaves of Strawberry tree …

Isolation and identification of some antibacterial peptides in the plasmin-digest of β-casein

M Sedaghati, H Ezzatpanah, MMA Boojar… - LWT-Food Science and …, 2016 - Elsevier
This study was an attempt to explore the antibacterial properties of plasmin and plasmin
generated peptides from bovine β-casein, and then to identify active peptides using RP …

Optimizing vancomycin dosing through pharmacodynamic assessment targeting area under the concentration-time curve/minimum inhibitory concentration

CA DeRyke, DP Alexander - Hospital Pharmacy, 2009 - journals.sagepub.com
Because of its activity against multidrug resistant gram-positive organisms, vancomycin is
one of the antimicrobials most utilized in health care systems worldwide. Despite its …

Antimicrobial management of complicated skin and skin structure infections in the era of emerging resistance

SY Lee, JL Kuti, DP Nicolau - Surgical infections, 2005 - liebertpub.com
Background: Complicated skin and skin structure infections (cSSSIs) are among the most
common infections treated in the hospital setting. The mainstays of treatment continue to be …

A systematic review and economic model of switching from non-glycopeptide to glycopeptide antibiotic prophylaxis for surgery

G Cranny, R Elliott, H Weatherly… - HEALTH …, 2008 - emerald.com
Background Surgical site infections (SSIs) are a major cause of morbidity and mortality in
surgical patients. Antibiotic prophylaxis is recommended when the risk of infection is high …