Most head and neck cancers are squamous cell carcinomas that develop in the upper
aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol …

Functional activation of growth factors and receptors of the epidermal growth factor receptor
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer …

Purpose Tumor antigen (TA)–targeted monoclonal antibodies (mAb), rituximab,
trastuzumab, and cetuximab, are clinically effective for some advanced malignancies …

Cancers of the stomach and esophagus are among the most challenging cancers of the GI
tract to treat, associated with poor median survivals for metastatic disease and significant …

Since the inception of this journal in 1948, the understanding of etiologic factors that
contribute to and the treatment of head and neck cancer has evolved dramatically. Advances …

Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic
drugs are available on the market, and several compounds are in different phases of clinical …

Head and neck squamous cell carcinoma (HNSCC) remains a significant public health
problem, accounting for over 5% of all cancer-related deaths, and these deaths primarily …

Loss of the maintenance of genetic material is a critical step leading to tumorigenesis. It was
reported that overexpression of Aurora-A and the constitutive activation of the epidermal …

Background We evaluated combined targeting with cetuximab, an anti-epidermal growth
factor receptor (EGFR) monoclonal antibody, and bevacizumab, an anti-vascular endothelial …

Abstract Novel thieno [2, 3-d] pyrimidine analogues were designed, synthesized and
evaluated for anti-proliferative activity against HepG-2, PC-3 and MCF-7 cancer cell lines. In …