DNA methylation is a well-studied epigenetic modification that has key roles in regulating
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …

Acetylation of histones is a key post-translational modification that guides gene expression
regulation. In yeast, the class I histone deacetylase containing Rpd3S complex plays a …

The post-translational modifications of histone H4 play significant roles in regulation of
epigenetic status. Reconstituted nucleosomes that mimic the native chromatin are valuable …

As a member of the histone deacetylase protein family, the NAD+-dependent SIRT6 plays
an important role in maintaining genomic stability and regulating cell metabolism …

Abstract Sirtuin 6 (SIRT6) is an NAD+-dependent histone H3 deacetylase that is prominently
found associated with chromatin, attenuates transcriptionally active promoters and regulates …

The sirtuins are NAD+‐dependent lysine deacylases, comprising seven isoforms (SIRT1–7)
in humans, which are involved in the regulation of a plethora of biological processes …

The tumor microenvironment plays a pivotal role in the metabolic reprogramming of cancer
cells. A better understanding of the underlying mechanisms regulating cancer metabolism …

Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell
damage. Continual functional decline in the intrinsic ability of living organisms to accurately …

Abstract Sirtuin 6 (SIRT6) is an NAD+-dependent histone H3 deacetylase that is prominently
found associated with chromatin, attenuates transcriptionally active promoters and regulates …