Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

This review provides a pulmonary-focused description of the age-associated changes in the
integrative physiology of exercise, including how declining lung function plays a role in …

Objective: Postmenopausal women exhibit elevated brachial-ankle pulse wave velocity
(baPWV), an indicator of arterial stiffness, which is associated with an increased risk of …

Abstract Aims Long non-coding RNAs (lncRNAs) have been shown to regulate numerous
processes in the human genome, but the function of these transcripts in vascular aging is …

Objective—Impaired endothelial cell (EC) autophagy compromises shear stress–induced
nitric oxide (NO) generation. We determined the responsible mechanism. Approach and …

Childhood obesity is strongly linked to pathological processes for cardiovascular diseases in
later adulthood. Obese adolescent girls with high blood pressure (BP) are reported to have …

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and
muscle function in the lower limbs. A skeletal muscle myopathy characterized by …

Blood velocity measured in the middle cerebral artery (MCAV) increases with finite kinetics
during moderate-intensity exercise, and the amplitude and dynamics of the response …

Aim This study sought to determine the role of free radicals derived from mitochondria in the
vasculature in the recognized age‐related endothelial dysfunction of human skeletal muscle …

Microvascular function is reduced with age, disease, and inactivity. Exercise is well known to
improve vascular health and has the potential to improve microvascular function in aging …