Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies
D Das, NR Shruthi, A Banerjee, G Jothimani… - Frontiers in …, 2023 - frontiersin.org
Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of
developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension …
developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension …
Exploiting the pleiotropic antioxidant effects of established drugs in cardiovascular disease
Cardiovascular disease is a leading cause of death and reduced quality of life worldwide.
Arterial vessels are a primary target for endothelial dysfunction and atherosclerosis, which is …
Arterial vessels are a primary target for endothelial dysfunction and atherosclerosis, which is …
Beta3-Adrenoreceptor Stimulation Ameliorates Myocardial Ischemia-Reperfusion Injury Via Endothelial Nitric Oxide Synthase and Neuronal Nitric Oxide Synthase …
JP Aragón, ME Condit, S Bhushan, BL Predmore… - Journal of the American …, 2011 - jacc.org
Objectives: This paper examined whether nebivolol protects the heart via nitric oxide (NO)
synthase and NO-dependent signaling in an in vivo model of acute myocardial infarction …
synthase and NO-dependent signaling in an in vivo model of acute myocardial infarction …
[HTML][HTML] Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial
A Cohen-Solal, D Kotecha… - European Journal of …, 2009 - Wiley Online Library
Aim To determine the safety and efficacy of nebivolol in elderly heart failure (HF) patients
with renal dysfunction. Methods and results SENIORS recruited patients aged 70 years or …
with renal dysfunction. Methods and results SENIORS recruited patients aged 70 years or …
The future of antihypertensive treatment
ZH Israili, R Hernández-Hernández… - American journal of …, 2007 - journals.lww.com
Despite progress in recent years in the prevention, detection, and treatment of high blood
pressure (BP), hypertension remains an important public health challenge. Hypertension …
pressure (BP), hypertension remains an important public health challenge. Hypertension …
Different pharmacological properties of two enantiomers in a unique β‐blocker, nebivolol
LJ Ignarro - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol is a racemic combination of d‐nebivolol (+ SRRR nebivolol) and l‐nebivolol (–
RSSS nebivolol) that differs chemically from other β‐blockers, with an absolutely …
RSSS nebivolol) that differs chemically from other β‐blockers, with an absolutely …
Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients
AF Pasini, U Garbin, C Stranieri… - American journal of …, 2008 - academic.oup.com
Background This study was conducted to evaluate (i) the effect of nebivolol, a selective β1-
adrenergic receptor antagonist, on plasma concentration of asymmetric dimethylarginine …
adrenergic receptor antagonist, on plasma concentration of asymmetric dimethylarginine …
Nebivolol: a review of its use in the management of hypertension and chronic heart failure
MD Moen, AJ Wagstaff - Drugs, 2006 - Springer
Nebivolol is a third-generation β-adrenoceptor antagonist. It differs from other β-
adrenoceptor antagonists as it combines highly selective β 1-adrenoceptor antagonist …
adrenoceptor antagonists as it combines highly selective β 1-adrenoceptor antagonist …
Direct demonstration of β1‐ and evidence against β2‐ and β3‐adrenoceptors, in smooth muscle cells of rat small mesenteric arteries
AM Briones, CJ Daly, F Jimenez‐Altayo… - British journal of …, 2005 - Wiley Online Library
Recent evidence supports additional subtypes of vasodilator β‐adrenoceptor (β‐AR)
besides the 'classical'β2. The aim of this study was to investigate the distribution of β‐ARs in …
besides the 'classical'β2. The aim of this study was to investigate the distribution of β‐ARs in …
Nebivolol: a third-generation β-adrenergic blocker
A Veverka, DS Nuzum, JL Jolly - Annals of …, 2006 - journals.sagepub.com
Objective: TO describe the pharmacologic and pharmacokinetic properties of a new β-
adrenergic blocker, nebivolol, and review the literature evaluating its efficacy in the …
adrenergic blocker, nebivolol, and review the literature evaluating its efficacy in the …