To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

Rab27, a member of the small GTPase Rab family, is widely conserved in metazoan, and
two Rab27 isoforms, Rab27A and Rab27B, are present in vertebrates. Rab27A was the first …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Summary von W illebrand factor (VWF) plays key roles in both primary and secondary
hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is …

Strict spatiotemporal control of trafficking events between organelles is critical for
maintaining homeostasis and directing cellular responses. This regulation is particularly …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

The vascular environment can rapidly alter, and the speed with which responses to both
physiological and pathological changes are required necessitates the existence of a highly …

Neutrophils respond nearly instantly to infection, rapidly deploying a potent enzymatic and
chemical arsenal immediately upon entering an infected site. This capacity for rapid and …

Endocytosis plays a crucial role in receptor signalling. VEGFR2 (also known as KDR) and its
ligand VEGFA are fundamental in neovascularisation. However, our understanding of the …