Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

SYNAPTOJANIN is a nerve terminal protein of relative molecular mass 145,000 which
appears to participate with dynamin in synaptic vesicle recycling1, 2. The central region of …

Interaction of extracellular-signal molecules with cell-surface receptors often activates a
phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other …

It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …

Gradients of PtdIns4 P between organelle membranes and the endoplasmic reticulum (ER)
are thought to drive counter-transport of other lipids via non-vesicular traffic. This novel …

In fungi and many other organisms, a thick outer cell wall is responsible for determining the
shape of the cell and for maintaining its integrity. The budding yeast Saccharomyces …

Although the actin cytoskeleton has been implicated in vesicle trafficking, docking and
fusion, its site of action and relation to the Ca (2+)-mediated activation of the docking and …

In this article, we will review recent progress in elucidating the mechanisms that regulate
phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and discuss advances in …