Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Endoplasmic reticulum–plasma membrane contact sites

Y Saheki, P De Camilli - Annual review of biochemistry, 2017 - annualreviews.org
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …

Synthesis and function of 3-phosphorylated inositol lipids

B Vanhaesebroeck, SJ Leevers… - Annual review of …, 2001 - annualreviews.org
▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

A presynaptic inositol-5-phosphatase

PS McPherson, EP Garcia, VI Slepnev, C David… - Nature, 1996 - nature.com
SYNAPTOJANIN is a nerve terminal protein of relative molecular mass 145,000 which
appears to participate with dynamin in synaptic vesicle recycling1, 2. The central region of …

Phospholipase D: molecular and cell biology of a novel gene family

M Liscovitch, M Czarny, G Fiucci, X TANG - Biochemical Journal, 2000 - portlandpress.com
Interaction of extracellular-signal molecules with cell-surface receptors often activates a
phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other …

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae

T Strahl, J Thorner - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2007 - Elsevier
It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

JP Zewe, RC Wills, S Sangappa, BD Goulden… - Elife, 2018 - elifesciences.org
Gradients of PtdIns4 P between organelle membranes and the endoplasmic reticulum (ER)
are thought to drive counter-transport of other lipids via non-vesicular traffic. This novel …

Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae

VJ Cid, A Durán, F del Rey, MP Snyder… - Microbiological …, 1995 - Am Soc Microbiol
In fungi and many other organisms, a thick outer cell wall is responsible for determining the
shape of the cell and for maintaining its integrity. The budding yeast Saccharomyces …

Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

S Muallem, K Kwiatkowska, X Xu, HL Yin - The Journal of cell biology, 1995 - rupress.org
Although the actin cytoskeleton has been implicated in vesicle trafficking, docking and
fusion, its site of action and relation to the Ca (2+)-mediated activation of the docking and …

Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes

GM Carman, SA Henry - Progress in lipid research, 1999 - Elsevier
In this article, we will review recent progress in elucidating the mechanisms that regulate
phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and discuss advances in …