It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …

Maladaptive changes of nerve injury–associated genes in dorsal root ganglia (DRGs) are
critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding …

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons,
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …

Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …

African Americans disproportionately suffer more severe and debilitating morbidity from
chronic pain than do non-Hispanic Whites. These differences may arise from differential …

Nerve injury‐induced maladaptive changes of gene expression in dorsal root ganglion
(DRG) neurons contribute to neuropathic pain. Long non‐coding RNAs (lncRNAs) are …

Chronic pain is ongoing pain that has persisted beyond standard tissue healing time along
with comorbidities such as depression. This article discusses studies that have shown the …

Background Traumatic brain injury refers to a broad range of neurological, cognitive, and
emotional factors that result from the application of an external force to the head. Individuals …

Neuropathic pain (NP) refers to pain caused by primary or secondary damage or dysfunction
of the peripheral or central nervous system, which seriously affects the physical and mental …