Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular
processes and are potential therapeutic targets owing to their involvement in diseases such …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Topoisomerases form transient covalent DNA cleavage complexes to perform their
reactions. Topoisomerase I cleavage complexes (TOP1ccs) are trapped by camptothecin …

Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-
translational modifications controlling intracellular signalling events. However, the ubiquitin …

The post-translational modification SUMOylation is a major regulator of protein function that
plays an important role in a wide range of cellular processes. SUMOylation involves the …

1 62.96 31.48 31.94 64.81 31.94 44.44 2 B 2 75.93 72.22 63.89 68.52 66.67 75.00 6 A 3
74.07 81.48 77.08 55.56 72.22 69.44 5 B 4 38.89 33.33 30.56 61.11 41.67 61.11 2 B 5 …

Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including
gene transcription, cell‐cycle progression, DNA repair, apoptosis, virus budding and …

In acute promyelocytic leukaemia (APL), the promyelocytic leukaemia (PML) protein is fused
to the retinoic acid receptor α (RAR). This disease can be treated effectively with arsenic …

Signalling networks regulate essentially all of the biology of cells and organisms in normal
and disease states. Signalling is often studied using antibody-based techniques such as …