Wakefulness and vigilance levels are required for maintaining purposeful activities and
motivated behaviours, which are often triggered by sensory information conveying external …

Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …

Objective In Alzheimer's disease, hyperphosphorylated tau is associated with formation of
insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are …

Orexin (hypocretin) peptides and their two known G‐protein‐coupled receptors play
essential roles in sleep–wake control and powerfully influence other systems regulating …

The orexin system comprises two G protein-coupled receptors, orexin 1 receptor (OX1R)
and orexin 2 receptor (OX2R), along with two endogenous agonists cleaved from a common …

Orexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic
neuropeptides highly conserved across mammalian species. Their effects are mediated by …

An array of neuromodulators, including monoamines and neuropeptides, regulate most
behavioural and physiological traits. In the past decade, dramatic progress has been made …

Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the
two G-protein-coupled receptors (GPCRs), named OX 1 and OX 2 orexin receptors, as …

Peptides promote the mitogenesis and migration of tumor cells, and cancer cells
overexpress peptide receptors. The involvement of the orexinergic system in cancer is …