Annexin A2 (A2) is a multicompartmental, multifunctional protein that orchestrates a growing
spectrum of biologic processes. At the endothelial cell surface, A2 and S100A10 (p11) form …

INTRODUCTION: Compared to bleeding, major thromboses are a less commonly
encountered problem in acute promyelocytic leukemia (APL), and our knowledge about the …

Hyperfibrinolysis is a systemic condition occurring in various clinical disorders such as
trauma, liver cirrhosis, and leukemia. Apart from increased bleeding tendency, the …

We previously demonstrated that serum levels of plasminogen activator inhibitor-1 (PAI-1),
which inhibits both the tissue plasminogen activator (tPA) and plasmin activity, are increased …

Acute promyelocytic leukemia (APL) is associated with a high risk of bleeding and
thrombosis. APL patients have an activated coagulation system, hyperfibrinolysis, and …

Abstract sulfur-containing amino acids have been reported to patriciate in gene regulation,
DNA methylation, protein synthesis and other physiological or pathological processes. In …

Since cancer cells have different mitochondrial bioenergetic requirements than non-
cancerous cells, therapeutic inhibition of its mitochondrial functionality continues to be an …

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are characterized by
risk of relapses, poor survival, unwanted side effects and high toxicity with the current …

Fibrinolysis is a complex process that controls both hemostasis and thrombosis. The
regulation of the fibrinolytic system is mediated through a wide array of cofactors and …

Despite the outstanding advances made over the past decade regarding our knowledge of
acute leukemia (AL), relapsed AL remains to be associated with a dismal prognosis. A better …