Membranes of mammalian subcellular organelles contain defined amounts of specific
phospholipids that are required for normal functioning of proteins in the membrane. Despite …

Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in
eukaryotic cells. The existence of four only partially redundant biochemical pathways that …

Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …

Mitochondrial structure and function are influenced by the unique phospholipid composition
of its membranes. While mitochondria contain all the major classes of phospholipids, recent …

Mitochondrial dysfunction is implicated in neurodegenerative, cardiovascular, and metabolic
disorders, but the role of phospholipids, particularly the nonbilayer-forming lipid …

Mitochondria are complex organelles with two membranes. Their architecture is determined
by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and …

Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is
synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and …

The mitochondrial inner membrane contains two non-bilayer‐forming phospholipids,
phosphatidylethanolamine (PE) and cardiolipin (CL). Lack of CL leads to destabilization of …

Glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins is the most complex
and metabolically expensive of the lipid posttranslational modifications described to date …

The membranes of mammalian cells contain hundreds of different phospholipid species, a
variety of glycolipids and cholesterol. While the reasons for such compositional diversity are …