How I manage children with neutropenia

DC Dale - British journal of haematology, 2017 - Wiley Online Library
Neutropenia, usually defined as a blood neutrophil count< 1· 5× 109/l, is a common medical
problem for children and adults. There are many causes for neutropenia, and at each stage …

Neonatal alloimmune neutropenia

L Porcelijn, M de Haas - Transfusion Medicine and Hemotherapy, 2018 - karger.com
Neonatal alloimmune neutropenia (NAIN, NAIN or NIN) is a neutrophil blood group
antagonism, analogous to hemolytic disease of the fetus and newborn (HDFN) and …

Targeted exome sequencing designed for blood group, platelet, and neutrophil antigen investigations: proof‐of‐principle study for a customized single‐test system

E Roulis, E Schoeman, M Hobbs, G Jones… - …, 2020 - Wiley Online Library
Background Immunohematology reference laboratories provide red blood cell (RBC),
platelet (PLT), and neutrophil typing to resolve complex cases, using serology and …

How we diagnose and treat neutropenia in adults

J Palmblad, CC Nilsson, P Höglund… - Expert review of …, 2016 - Taylor & Francis
Neutropenias (NPs), being acute and often transient, or chronic, range from life-threatening
conditions with very low absolute neutrophil blood counts (ANC) to disorders characterized …

[PDF][PDF] Review of fetal and neonatal immune cytopenias

S Lewin, JB Bussel - Clin Adv Hematol Oncol, 2015 - hematologyandoncology.net
The fetoplacental interface plays a unique role in pathologies of the fetus and neonate, and
is increasingly being recognized for effects on fetal and neonatal development that resonate …

Neonatal immune incompatibilities between newborn and mother

B Arneth - Journal of clinical medicine, 2020 - mdpi.com
Background: Incompatibilities between the mother and unborn baby can cause
complications that must be identified early to initiate the appropriate treatment. For example …

Two cases of maternal alloimmunization against human neutrophil alloantigen‐4b, one causing severe alloimmune neonatal neutropenia

BR Curtis, AS Roman, MJ Sullivan, CS Raven… - …, 2016 - Wiley Online Library
BACKGROUND Human neutrophil antigen (HNA)− 4a/4bw is encoded by 230G> A in
ITGAM, which results in an Arg61His substitution of the αM chain (CD11b) of complement …

Assessment of HNA alloimmunisation risk in Northeastern Thais, Burmese and Karen

P Simtong, C Puapairoj, C Leelayuwat… - Transfusion …, 2018 - Wiley Online Library
Objectives This study aimed to determine human neutrophil antigen (HNA) frequency,
estimate possible HNA incompatibilities and predict the risk of HNA alloimmunisation in the …

Neonatal alloimmune neutropenia: diagnosis and management of 31 Italian patients

A Cattaneo, M Liguori, E Trombetta, F Ceriotti… - Blood …, 2022 - pmc.ncbi.nlm.nih.gov
Background In neonates, antibody-mediated destruction of neutrophils may occur as a
consequence of auto-or isoimmune disorders. There are few studies on this topic, and …

Production of recombinant humanized monoclonal anti‐human neutrophil antigen (HNA) antibodies with potential applicability as standard antibodies

Y Ishimoto, K Taniguchi, B Bayat, R Tobita… - …, 2023 - Wiley Online Library
Background Antibodies against human neutrophil antigen (HNA) are involved in the
pathogenesis of neonatal alloimmune neutropenia, autoimmune neutropenia, and …