Purpose Most patients who undergo surgery or experience a traumatic injury suffer from
acute pain that subsides once tissues heal. Nevertheless, the pain remains in 15-30% of …

A multiplex analysis for profiling the expression of candidate genes along with epigenetic
modification may lead to a better understanding of the complex machinery of neuropathic …

Background Peripheral nerve injury leads to changes in gene expression in primary sensory
neurons of the injured dorsal root ganglia. These changes are believed to be involved in …

The neuropathic pain model consisting of the spared nerve injury of the sciatic nerve was
used in the mouse to examine whether peripheral neuropathy is capable of generating over …

Neuropathic pain induced by sciatic nerve injury not only causes peripheral dysfunctions but
also affects the cortical and subcortical regions of the brain. It is still unknown whether …

Peripheral nerve injury may lead to neuroadaptive changes of cellular signals in spinal cord
that are thought to contribute to central mechanisms underlying neuropathic pain. Here we …

The previous studies showed that alternatively activated anti-inflammatory macrophage (M2)
adoptive immunity can improve the proportion of local M2 cells and play the neuroprotective …

There is convincing evidence that nitric oxide (NO), cGMP and cGMP-dependent protein
kinase I (PKG-I) are involved in the development of hyperalgesia in response to noxious …

p21-activated kinases (PAKs) are involved in signal cascades relevant for nociceptive
processing and neuropathic pain. Particularly, the recently described group B PAKs 4, 5 and …

Ten patients undergo a similar surgical procedure, incurring similar degrees of nerve
damage. One of them goes on to develop a debilitating neuropathic pain condition. What …