Metalloporphyrins are widely used throughout the biosphere, and of these heme (iron
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …

Covering: up to 2006 Heme oxygenase (HO) catalyzes O2-dependent regiospecific
conversion of heme to biliverdin, CO and free Fe (II). The heme group is tightly sandwiched …

The maintenance of functional chloroplasts in photosynthetic eukaryotes requires real-time
coordination of the nuclear and plastid genomes. Tetrapyrroles play a significant role in …

No other bacterial genus has been brought into context with so many different aspects of
public interest as that of Pseudomonas (439): Pseudomonas aeruginosa is the germ …

The importance of heme oxygenases in heme catabolism, iron utilization, and cellular
signaling has been recognized for many years and is a well studied process in eukaryotes …

The Gram-negative bacterium Pseudomonas aeruginosa contains a heme oxygenase (pa-
HO) that primarily oxygenates the δ-meso heme carbon [Caignan, GA, Deshmukh, R., Wilks …

Pseudomonas aeruginosa PAO1 encodes two outer membrane receptors, PhuR
(Pseudomonas heme uptake) and HasR (heme assimilation system). The HasR and PhuR …

Heme oxygenases (HOs) catalyze the oxidation of heme to biliverdin, carbon monoxide
(CO), and free iron. Iron acquisition is critical for invading microorganisms to enable survival …

Hemin triggers intracellular reactive oxygen species (ROS) accumulation and enhances
heme oxygenase-1 (HOX-1) activity, indicating its potential as an anticancer agent, though …

For many pathogenic bacteria like Pseudomonas aeruginosa heme is an essential source of
iron. After uptake, the heme molecule is degraded by heme oxygenases to yield iron, carbon …