The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
S Datta, M Cano, K Ebrahimi, L Wang… - Progress in retinal and …, 2017 - Elsevier
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
Ocular drug delivery to the retina: current innovations and future perspectives
HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …
Microglia in the retina: roles in development, maturity, and disease
SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
New advances in general biomedical applications of PAMAM dendrimers
Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally
considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by …
considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by …
A new era in posterior segment ocular drug delivery: Translation of systemic, cell-targeted, dendrimer-based therapies
Vision impairment and loss due to posterior segment ocular disorders, including age-related
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …
[HTML][HTML] Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies
There is an increasing momentum in research and pharmaceutical industry communities to
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …
[HTML][HTML] Targeting mitochondrial dysfunction and oxidative stress in activated microglia using dendrimer-based therapeutics
Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …
Multi-component herbal products in the prevention and treatment of chemotherapy-associated toxicity and side effects: a review on experimental and clinical …
B Fu, N Wang, HY Tan, S Li, F Cheung… - Frontiers in …, 2018 - frontiersin.org
Chemotherapy is nowadays the main treatment of human cancers. Chemotherapeutic
agents target rapidly dividing cancer cells to suppress tumor progression, however, their non …
agents target rapidly dividing cancer cells to suppress tumor progression, however, their non …
Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation
Corneal inflammation is often encountered as a key pathological event in many corneal
diseases. Current treatments involve topical corticosteroids which require frequent …
diseases. Current treatments involve topical corticosteroids which require frequent …
Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury
Traumatic brain injury (TBI) is a significant medical problem with limited treatment options
and is one of the main causes of life-long disability. Neuroinflammation orchestrated by …
and is one of the main causes of life-long disability. Neuroinflammation orchestrated by …