Over the past five years, a rapidly developing experimental approach has enabled high-
resolution and high-content information retrieval from intact multicellular animal (metazoan) …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

CLARITY is a tissue clearing method, which enables immunostaining and imaging of large
volumes for 3D-reconstruction. The method was initially time-consuming, expensive and …

A key challenge when imaging whole biomedical specimens is how to quickly obtain
massive cellular information over a large field of view (FOV). We report a subvoxel light …

Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive
understanding of the heart and its functions at various levels, from the molecular to the entire …

Light‐sheet microscopy (LSM) enables us to strengthen the understanding of cardiac
development, injury, and regeneration in mammalian models. This emerging technique …

The ability to image tissue morphogenesis in real-time and in 3-dimensions (3-D) remains
an optical challenge. The advent of light-sheet fluorescence microscopy (LSFM) has …

Background Reendothelialisation is the natural pathway that inhibits neointimal hyperplasia
and in-stent restenosis. Circulating endothelial progenitor cells (EPCs) derived from bone …

Rationale: Remodeling of the vessel wall and the formation of vascular networks are
dynamic processes that occur during mammalian embryonic development and in adulthood …

Autofluorescence (AF) poses challenges for detecting proteins of interest in situ when
employing immunofluorescence (IF) microscopy. This interference is particularly …