The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Each meal is
a potential infection because some bacteria have evolved mechanisms to resist predation …

Autophagy is an evolutionarily conserved multistep degradation mechanism in eukaryotes,
that maintains cellular homoeostasis by replenishing cells with nutrients through catabolic …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across
eukaryotes. Autophagy-related (ATG) genes have undergone extensive multiplications and …

Many cancers, including pancreatic ductal adenocarcinoma (PDAC), depend on autophagy-
mediated scavenging and recycling of intracellular macromolecules, suggesting that …

Autophagy is a universal cellular homeostatic process, required for the clearance of
dysfunctional macromolecules or organelles. This self-digestion mechanism modulates cell …

Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …

Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. This severe stress is …

Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence.
Infected host cells generate double-membrane autophagosomes that mature in …

Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular
degradation pathways, which are critical for the maintenance of cell homeostasis. The two …