Illuminating dendritic function with computational models

P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Circuit investigations with open-source miniaturized microscopes: past, present and future

D Aharoni, TM Hoogland - Frontiers in cellular neuroscience, 2019 - frontiersin.org
The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

The brain in motion: How ensemble fluidity drives memory-updating and flexibility

W Mau, ME Hasselmo, DJ Cai - Elife, 2020 - elifesciences.org
While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …

NINscope, a versatile miniscope for multi-region circuit investigations

A de Groot, BJG van den Boom, RM van Genderen… - Elife, 2020 - elifesciences.org
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor
neural signals during unrestrained behavior and their open-source versions have made …

Miniscope-LFOV: a large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals

C Guo, GJ Blair, M Sehgal, FN Sangiuliano Jimka… - Science …, 2023 - science.org
Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger
than mice remains a key endeavor of neuroscience. We present a large-field-of-view open …

ezTrack: An open-source video analysis pipeline for the investigation of animal behavior

ZT Pennington, Z Dong, Y Feng, LM Vetere… - Scientific reports, 2019 - nature.com
Tracking animal behavior by video is one of the most common tasks in the life sciences.
Although commercial software exists for executing this task, they often present enormous …

A stable hippocampal code in freely flying bats

WA Liberti III, TA Schmid, A Forli, M Snyder… - Nature, 2022 - nature.com
Neural activity in the hippocampus is known to reflect how animals move through an
environment,. Although navigational behaviour may show considerable stability,,–, the …

A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging

L Sità, M Brondi, P Lagomarsino de Leon Roig… - Nature …, 2022 - nature.com
In vivo two-photon calcium imaging is a powerful approach in neuroscience. However,
processing two-photon calcium imaging data is computationally intensive and time …

Modulation of brain hyperexcitability: potential new therapeutic approaches in Alzheimer's disease

S Toniolo, A Sen, M Husain - International journal of molecular sciences, 2020 - mdpi.com
People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking

CJ Gabriel, Z Zeidler, B Jin, C Guo, CM Goodpaster… - Elife, 2022 - elifesciences.org
Quantitative descriptions of animal behavior are essential to study the neural substrates of
cognitive and emotional processes. Analyses of naturalistic behaviors are often performed …