Insulin-like growth factors (IGFs) bind specifically to the IGF1 receptor on the cell surface of
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …

The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …

Epidemiological and basic science evidence suggest a possible shared pathophysiology
between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). It has even been …

Insulin receptors are known to be located on nerve cells in mammalian brain. The binding of
insulin to dimerized receptors stimulates specialized transporter proteins that mediate the …

FIG. 1. Schematic representation of the MPRs. 0, N-linked glycosylation 13 of the CI-MPR
represents the region that is similar to the type I1 repeats of fibronectin. Modified from Ref …

Insulin resistance is a major factor in the pathophysiology of type II diabetes and a major
impediment to successful therapy. The identification of treatments that specifically target …

Insulin is a potent mitogen for many cell types in vitro. During tissue culture,
supraphysiological concentrations of insulin are necessary to promote cell replication in …

Serum levels of immunoreactive insulinlike growth factors (IGF) I and II were determined by
a modified IGF I and a new IGF II radioimmunoassay in normal children and adults, and in …

Stable transfectants of Chinese hamster ovary (CHO) cells were developed that expressed
the protein encoded by a human insulin-like growth factor I (IGF-I) receptor cDNA. The …

Insulin and the insulin-like growth factors (IGF-I, IGF-II) are pleiotropic hormones that have
multiple roles in regulating vital metabolic and developmental processes. Although most …