Polyphenols and fish oils for improving metabolic health: a revision of the recent evidence for their combined nutraceutical effects

L Méndez, I Medina - Molecules, 2021 - mdpi.com
Polyphenols and omega-3 polyunsaturated fatty acids from fish oils, ie, eicosapentaenoic
and docosahexaenoic acids, are well-recognized nutraceuticals, and their single antioxidant …

[HTML][HTML] Combined drug triads for synergic neuroprotection in retinal degeneration

V Maneu, P Lax, AMG De Diego, N Cuenca… - Biomedicine & …, 2022 - Elsevier
This review focuses on retina degeneration occurring during glaucoma, age-related macular
degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), and on the …

Antisense Oligonucleotide-Based Rescue of Aberrant Splicing Defects Caused by 15 Pathogenic Variants in ABCA4

TZ Tomkiewicz, N Suárez-Herrera… - International journal of …, 2021 - mdpi.com
The discovery of novel intronic variants in the ABCA4 locus has contributed significantly to
solving the missing heritability in Stargardt disease (STGD1). The increasing number of …

A novel lipophenol quercetin derivative to prevent macular degeneration: Intravenous and oral formulations for preclinical pharmacological evaluation

M Vincent, J Lehoux, C Desmarty, E Moine… - International Journal of …, 2024 - Elsevier
Drugs with properties against oxidative and carbonyl stresses are potential candidates to
prevent dry age-related macular degeneration (Dry-AMD) and inherited Stargardt disease …

Formulation and evaluation of SNEDDS loaded with original lipophenol for the oral route to prevent dry AMD and Stragardt's disease

M Vincent, L Simon, P Brabet, P Legrand, C Dorandeu… - Pharmaceutics, 2022 - mdpi.com
Dry age-related macular degeneration (Dry AMD) and Stargardt's disease (STGD1) are
common eye diseases, characterized by oxidative and carbonyl stress (COS)-inducing …

New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration

E Moine, M Boukhallat, D Cia, N Jacquemot… - Free Radical Biology …, 2021 - Elsevier
Dry age-related macular degeneration and Stargardt disease undergo a known toxic
mechanism caused by carbonyl and oxidative stresses (COS). This is responsible for …

Overview of alkyl quercetin lipophenol synthesis and its protective effect against carbonyl stress involved in neurodegeneration

L Otaegui, J Lehoux, L Martin, L Givalois… - Organic & …, 2024 - pubs.rsc.org
Oxidative stress and carbonyl stress resulting from the toxicity of small aldehydes are part of
the detrimental mechanisms leading to neuronal cell loss involved in the progression of …

Synthesis of Fatty Acid Bioconjugates and Related Derivatives

C Crauste, JM Galano, A Guy, J Lehoux… - European Journal of …, 2022 - Wiley Online Library
Synthesis of Fatty Acid Bioconjugates and Related Derivatives - Crauste - 2022 - European
Journal of Organic Chemistry - Wiley Online Library Skip to Article Content Skip to Article …

Understanding disease mechanisms and developing new therapies for RDH12-related retinopathies

H Sarkar - 2022 - discovery.ucl.ac.uk
Retinol dehydrogenase 12 (RDH12) is expressed in photoreceptor inner segments and
catalyses the reduction of all-trans retinal (atRAL) to all-trans retinol as part of the visual …

[HTML][HTML] To Study the Experimental Model of Age-Related Macular Degeneration (ARMD)

YK Cho, DH Park, IC Jeon - The Korean Journal of Vision …, 2022 - online-koptometry.net
We investigated the experimental model papers on age-related macular degeneration
(ARMD), one of the world's four major blindness diseases, we intend to suggest the future …