Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
Autoimmune pre-disease
Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …
[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
IgA subclasses have different effector functions associated with distinct glycosylation profiles
U Steffen, CA Koeleman, MV Sokolova, H Bang… - Nature …, 2020 - nature.com
Monomeric serum immunoglobulin A (IgA) can contribute to the development of various
autoimmune diseases, but the regulation of serum IgA effector functions is not well defined …
autoimmune diseases, but the regulation of serum IgA effector functions is not well defined …
mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses …
JS Buhre, T Pongracz, I Künsting, AS Lixenfeld… - Frontiers in …, 2023 - frontiersin.org
Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …
[HTML][HTML] Nanodiamonds with powerful ability for drug delivery and biomedical applications: Recent updates on in vivo study and patents
Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating
mechanical, chemical, optical and biological properties, making them significant active …
mechanical, chemical, optical and biological properties, making them significant active …
Expression system for structural and functional studies of human glycosylation enzymes
KW Moremen, A Ramiah, M Stuart, J Steel… - Nature chemical …, 2018 - nature.com
Vertebrate glycoproteins and glycolipids are synthesized in complex biosynthetic pathways
localized predominantly within membrane compartments of the secretory pathway. The …
localized predominantly within membrane compartments of the secretory pathway. The …
Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells
B Föh, JS Buhre, HB Lunding, ME Moreno-Fernandez… - Plos one, 2022 - journals.plos.org
The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory
innate and adaptive immune responses. Emerging evidence suggests that butyrate induces …
innate and adaptive immune responses. Emerging evidence suggests that butyrate induces …
Potential of murine IgG1 and human IgG4 to inhibit the classical complement and Fcγ receptor activation pathways
GM Lilienthal, J Rahmöller, J Petry, YC Bartsch… - Frontiers in …, 2018 - frontiersin.org
IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ
receptors (FcγRs) and the complement factors. The main IgG-mediated complement …
receptors (FcγRs) and the complement factors. The main IgG-mediated complement …
[HTML][HTML] IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants
Background Effector functions of IgG Abs are regulated by their Fc N-glycosylation pattern.
IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the …
IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the …