Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches

A Mehmandar-Oskuie, K Jahankhani, A Rostamlou… - Life Sciences, 2024 - Elsevier
Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …

Translation of cell therapies to treat autoimmune disorders

JM Mehta, SC Hiremath, C Chilimba, A Ghasemi… - Advanced Drug Delivery …, 2024 - Elsevier
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

Regulatory T Cells and Their Derived Cell Pharmaceuticals as Emerging Therapeutics Against Autoimmune Diseases

L Yu, Y Fu, R Miao, J Cao, F Zhang… - Advanced Functional …, 2024 - Wiley Online Library
Caused by the loss in the tolerance against self‐antigens, autoimmune diseases are chronic
disorders that impact millions of individuals annually with significant economic burden. They …

Genetic and Epigenetic Association of FOXP3 with Papillary Thyroid Cancer Predisposition

C Achilla, A Chorti, T Papavramidis, L Angelis… - International Journal of …, 2024 - mdpi.com
Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy with an
increased female incidence ratio. The specific traits of X chromosome inheritance may be …

Causal associations of immune cell phenotypes with migraine: A mendelian randomization study

W Chai, W Chai, F Guo - Molecular Pain, 2024 - journals.sagepub.com
The interaction between the immune system and the brain, crucial for blood–brain barrier
integrity, is a potential factor in migraine development. Although there's evidence of a …

[HTML][HTML] Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ …

HC Chuang, JH Chang, YY Fan, CL Hsieh… - Biomedicine & …, 2024 - Elsevier
Allergic asthma is a chronic disease tied to unusual immune reactions involving type 2 T
helper (Th2) cells specific to allergens. Dendritic cells (DCs) play a crucial role in guiding T …

[HTML][HTML] Oral squamous cell carcinomas drive monocytes into immunosuppressive CD25+ CD163+ CD206+ macrophages

HF Pelaez-Prestel, F Gonzalez-Martin, A Ras-Carmona… - Oral Oncology, 2024 - Elsevier
Tumor-associated macrophages (TAMs) are major cellular components in the tumor
microenvironment of oral squamous cell carcinomas (OSCCs). Most of these TAMs derive …

[HTML][HTML] Biomaterial-enhanced treg cell immunotherapy: A promising approach for transplant medicine and autoimmune disease treatment

K Mashayekhi, K Khazaie, WA Faubion Jr, GB Kim - Bioactive Materials, 2024 - Elsevier
Regulatory T cells (Tregs) are crucial for preserving tolerance in the body, rendering Treg
immunotherapy a promising treatment option for both organ transplants and autoimmune …

Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus

S Huang, F Li, C Quan, D Jin - Gut Microbes, 2024 - Taylor & Francis
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by
destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, and its …

An updated overview of the application of CAR‐T cell therapy in neurological diseases

H Shahabifard, M Zarei, K Kookli… - Biotechnology …, 2023 - Wiley Online Library
Genetically modified immune cells, especially CAR‐T cells, have captured the attention of
scientists over the past 10 years. In the fight against cancer, these cells have a special place …