Understanding the origin of cellular life on Earth requires the discovery of plausible
pathways for the transition from complex prebiotic chemistry to simple biology, defined as …

The RNA world hypothesis regarding the early evolution of life relies on the premise that
some RNA sequences can catalyze RNA replication. In support of this conjecture, we …

In this review, we examine the interaction of nucleic acids with cell-like structures based on
liquid–liquid phase separation of charged molecules (complex coacervation) and …

Primordial organisms of the putative RNA world would have required polymerase ribozymes
able to replicate RNA. Known ribozymes with polymerase activity best approximating that …

The theory that an RNA world played a pivotal role in life's evolutionary past has prompted
investigations into the scope of RNA catalysis. These efforts have attempted to demonstrate …

All life on earth can be naturally classified into cellular life forms and virus-like selfish
elements, the latter being fully dependent on the former for their reproduction. Cells are …

Early life presumably required polymerase ribozymes capable of replicating RNA. Known
polymerase ribozymes best approximating such replicases use as their catalytic engine an …

Abstract Recursive Fractal Genome Function in the geometric mind frame of Tensor Network
Theory (TNT) leads through FractoGene to a mathematical unification of physiological and …

The class I ligase, a ribozyme previously isolated from random sequence, catalyzes a
reaction similar to RNA polymerization, positioning its 5 '-nucleotide via a Watson− Crick …

Early in the evolution of life a proto-metabolic network was encapsulated within a membrane
compartment. The permeability characteristics of the membrane determined several key …