James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …

Parvalbumin-expressing interneurons (PV-INs) are highly vulnerable to stressors and have
been implicated in many neuro-psychiatric diseases such as schizophrenia, Alzheimer's …

Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …

Fast-spiking, inhibitory interneurons–prototype is the parvalbumin-positive (PV+) basket cell–
generate action potentials at high frequency and synchronize the activity of numerous …

Nutrient pollution of freshwater ecosystems results in predictable increases in carbon (C)
sequestration by algae. Tests of nutrient enrichment on the fates of terrestrial organic C …

Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

Seizures are often the key manifestation of neurological diseases caused by pathogenic
mutations in 169 of the genes that have so far been identified to affect mitochondrial …

Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons
and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to …