[HTML][HTML] Methotrexate an old drug with new tricks
Y Bedoui, X Guillot, J Sélambarom, P Guiraud… - International journal of …, 2019 - mdpi.com
Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-
rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug …
rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug …
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review
W Wang, H Zhou, L Liu - European journal of medicinal chemistry, 2018 - Elsevier
Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …
[HTML][HTML] Overview of methotrexate toxicity: a comprehensive literature review
KM Hamed, IM Dighriri, AF Baomar, BT Alharthy… - Cureus, 2022 - ncbi.nlm.nih.gov
Methotrexate (MTX) is significantly more effective than and has a considerable advantage
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …
Restorative effects of ethanolic leaf extract of Datura stramonium against methotrexate-induced hematological impairments
One of the prominent complications observed in those undergoing treatment with
methotrexate (MTX) is hematological profile alterations which could culminate in severe …
methotrexate (MTX) is hematological profile alterations which could culminate in severe …
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases
A Perl - Nature Reviews Rheumatology, 2016 - nature.com
Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …
[HTML][HTML] Mesenchymal stem cell-based therapy for rheumatoid arthritis
M Sarsenova, A Issabekova, S Abisheva… - International journal of …, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …
[HTML][HTML] Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis
SA Clayton, L MacDonald… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …
metabolism. They also act as important signalling hubs, and their dynamic regulation in …
Metabolism as a target for modulation in autoimmune diseases
N Huang, A Perl - Trends in immunology, 2018 - cell.com
Metabolic pathways are now well recognized as important regulators of immune
differentiation and activation, and thus influence the development of autoimmune diseases …
differentiation and activation, and thus influence the development of autoimmune diseases …
[HTML][HTML] Mitochondrial dysfunction in rheumatoid arthritis
C Ma, J Wang, F Hong, S Yang - Biomolecules, 2022 - mdpi.com
Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized
by excessive proliferation of synovial cells, massive production of inflammatory cells and …
by excessive proliferation of synovial cells, massive production of inflammatory cells and …
Apigenin alleviates methotrexate-induced liver and kidney injury in mice
F Sahindokuyucu-Kocasari, Y Akyol… - Human & …, 2021 - journals.sagepub.com
Methotrexate (MTX) is a drug used in the treatment of various types of cancer and
inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin …
inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin …