Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-
rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug …

Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …

Methotrexate (MTX) is significantly more effective than and has a considerable advantage
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …

One of the prominent complications observed in those undergoing treatment with
methotrexate (MTX) is hematological profile alterations which could culminate in severe …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …

Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …

Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Metabolic pathways are now well recognized as important regulators of immune
differentiation and activation, and thus influence the development of autoimmune diseases …

Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized
by excessive proliferation of synovial cells, massive production of inflammatory cells and …

Methotrexate (MTX) is a drug used in the treatment of various types of cancer and
inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin …