Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport …

Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that
tumor-associated inflammatory cells may modify lung tumor growth and invasiveness,. To …

Endocytosis of cell surface receptors is an important regulatory event in signal transduction.
The transforming growth factor β (TGF-β) superfamily signals to the Smad pathway through …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Autophagy is a normal degradative pathway that involves the sequestration of cytoplasmic
components and organelles in a vacuole called an autophagosome that finally fuses with …

Members of the Rab or ARF/Sar branches of the Ras GTPase superfamily regulate almost
every step of intracellular membrane traffic. A rapidly growing body of evidence indicates …

▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …

Signals generated in response to extracellular stimuli at the plasma membrane are
transmitted through cytoplasmic transduction cascades to the nucleus. We report the …