The evolving translational potential of small extracellular vesicles in cancer

A Möller, RJ Lobb - Nature Reviews Cancer, 2020 - nature.com
Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …

[HTML][HTML] Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

A Thakur, DC Parra, P Motallebnejad, M Brocchi… - Bioactive materials, 2022 - Elsevier
Cancer is a deadly disease that is globally and consistently one of the leading causes of
mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy …

[HTML][HTML] Exosome-mediated metastasis: communication from a distance

I Wortzel, S Dror, CM Kenific, D Lyden - Developmental cell, 2019 - cell.com
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating
cancer and a major cause of cancer mortality. Cell-cell communication via extracellular …

[HTML][HTML] RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field

BS Ludwig, H Kessler, S Kossatz, U Reuning - Cancers, 2021 - mdpi.com
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

[HTML][HTML] Exosomes in cancer: small particle, big player

X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …

Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds

AA Farooqi, NN Desai, MZ Qureshi… - Biotechnology …, 2018 - Elsevier
A rapidly growing body of experimental evidence has begun to shed light on the wide
ranging molecular mechanisms which modulate intra-and inter-cellular communications. A …

[HTML][HTML] The origin and functions of exosomes in cancer

C Rajagopal, KB Harikumar - Frontiers in oncology, 2018 - frontiersin.org
Exosomes are nanovesicles having a maximum size of 150 nm and is a newly emerging
focus in various fields of research. Its role in cargo trafficking along with its differential …

[HTML][HTML] The role of tumor microenvironment in therapeutic resistance

B Son, S Lee, HS Youn, EG Kim, W Kim, BH Youn - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cancer cells undergo unlimited progression and survival owing to activation of oncogenes.
However, support of the tumor microenvironment is essential to the formation of clinically …

Extracellular vesicles exploit viral entry routes for cargo delivery

HM Van Dongen, N Masoumi, KW Witwer… - Microbiology and …, 2016 - Am Soc Microbiol
Extracellular vesicles (EVs) have emerged as crucial mediators of intercellular
communication, being involved in a wide array of key biological processes. Eukaryotic cells …

[HTML][HTML] Extracellular vesicles: Critical players during cell migration

BH Sung, CA Parent, AM Weaver - Developmental cell, 2021 - cell.com
Cell migration is essential for the development and maintenance of multicellular organisms,
contributing to embryogenesis, wound healing, immune response, and other critical …