Advances in human oxytocin measurement: challenges and proposed solutions

BA Tabak, G Leng, A Szeto, KJ Parker… - Molecular …, 2023 - nature.com
Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes,
may hold promise as a therapeutic agent in treating social impairments in patient …

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

[HTML][HTML] Childhood maltreatment and DNA methylation: A systematic review

CAM Cecil, Y Zhang, T Nolte - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

Oxytocin and the neurobiology of prosocial behavior

N Marsh, AA Marsh, MR Lee… - The …, 2021 - journals.sagepub.com
Humans are an unusually prosocial species, who engage in social behaviors that include
altruism—whereby an individual engages in costly or risky acts to improve the welfare of …

Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation

BJ Ellis, AJ Horn, CS Carter, MH van IJzendoorn… - Clinical Psychology …, 2021 - Elsevier
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior,
surprisingly little is known about how this neuropeptide is calibrated during development …

Glucocorticoid signaling and epigenetic alterations in stress-related disorders

N Mourtzi, A Sertedaki, E Charmandari - International Journal of …, 2021 - mdpi.com
Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

Roles of the oxytocin receptor (OXTR) in human diseases

K Pierzynowska, L Gaffke, M Żabińska, Z Cyske… - International journal of …, 2023 - mdpi.com
The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal
transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in …

[HTML][HTML] The physiology and pharmacology of oxytocin in labor and in the peripartum period

K Uvnäs-Moberg - American journal of obstetrics and gynecology, 2024 - Elsevier
Oxytocin is a reproductive hormone implicated in the process of parturition and widely used
during labor. Oxytocin is produced within the supraoptic nucleus and paraventricular …

Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review

J Kohlhoff, S Cibralic, DJ Hawes, V Eapen - Neuroscience & Biobehavioral …, 2022 - Elsevier
This study systematically reviewed available evidence regarding associations between
polymorphisms of the oxytocin receptor (OXTR) gene and socio-emotional and behavioral …

Maternal caregiving and DNA methylation in human infants and children: Systematic review

L Provenzi, M Brambilla… - Genes, Brain and …, 2020 - Wiley Online Library
The integration of behavioral epigenetics' principles (eg, DNA methylation) into the study of
human infants' development has mainly focused on the effects of early adverse exposures …