Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist first developed as an
anesthetic, has shown significant promise as a medication with rapid antidepressant …

The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …

Modern research data suggest a therapeutic role for serotonergic psychedelics in
depression and other neuropsychiatric disorders, although psychotomimetic effects may limit …

In recent years, psychedelics have generated considerable excitement and interest as
potential novel therapeutics for an array of conditions, with the most advanced evidence …

Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of
disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an …

Saliva has significantly evolved as a diagnostic fluid in recent years, giving a non-invasive
alternative to blood analysis. A high protein concentration in saliva is delivered directly from …

Background Subanesthetic ketamine has accumulated meta-analytic evidence for rapid
antidepressant effects in treatment-resistant depression (TRD), resulting in both excitement …

Our previous studies have reported that pre-stimulation of microglia before stress stimulation
is a possible strategy to prevent depression-like phenotypes; however, the molecular …

Ring-substituted phenethylamines are believed to induce psychedelic effects primarily by
interacting with 5-hydroxytryptamine 2 (5-HT2A) receptors in the brain. We assessed the …

“Learned helplessness” refers to debilitating outcomes, such as passivity and increased
fear, that follow an uncontrollable adverse event, but do not when that event is controllable …