Dynamic interactomics by cross-linking mass spectrometry: mapping the daily cell life in postgenomic era

L Santorelli, M Caterino, M Costanzo - OMICS: A Journal of …, 2022 - liebertpub.com
The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

The serum metabolome of moderate and severe COVID-19 patients reflects possible liver alterations involving carbon and nitrogen metabolism

M Caterino, M Costanzo, R Fedele, A Cevenini… - International journal of …, 2021 - mdpi.com
COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical
sequelae and deaths, in the context of a world pandemic. The infection of the highly …

The modifying effect of obesity on the association of matrix metalloproteinase gene polymorphisms with breast cancer risk

N Pavlova, S Demin, M Churnosov, E Reshetnikov… - Biomedicines, 2022 - mdpi.com
Objective: We investigated the possible modifying effect of obesity on the association of
matrix metalloproteinase (MMP) gene polymorphisms with breast cancer (BC) risk. Methods …

Mass spectrometry-based N-glycosylation analysis in kidney disease

W Ren, Q Bian, Y Cai - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Kidney disease is a global health concern with an enormous expense. It is estimated that
more than 10% of the population worldwide is affected by kidney disease and millions of …

Posttranslational modifications pattern in clear cell renal cell carcinoma

CD Ene, MN Penescu, SR Georgescu, M Tampa… - Metabolites, 2020 - mdpi.com
Posttranslational modifications are dynamic enzymatic-mediated processes, regulated in
time and space, associated with cancer development. We aimed to evaluate the significance …

[HTML][HTML] A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults

C Wen, H Wang, H Wang, H Mo, W Zhong… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Evidences shows that immune and stroma related genes in the tumour microenvironment
(TME) play a key regulator in the prognosis of Osteosarcomas (OSs). The purpose of this …

Quantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell renal cell carcinoma

A Senturk, AT Sahin, A Armutlu, MC Kiremit… - Molecular cancer …, 2021 - AACR
Clear cell renal cell carcinoma (ccRCC) is the third most common and most malignant
urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors …

The labyrinth of renal cell carcinoma

C Manini, JI López - Cancers, 2020 - mdpi.com
Renal cell carcinoma (RCC) ranks in the top-ten list of malignancies both in males and
females [1], and its frequency is increasing as a consequence of the increase in aging and …

Proteomic approaches for characterizing renal cell carcinoma

DJ Clark, H Zhang - Clinical Proteomics, 2020 - Springer
Renal cell carcinoma is among the top 15 most commonly diagnosed cancers worldwide,
comprising multiple sub-histologies with distinct genomic, proteomic, and clinicopathological …

Proteomics and Metabolomics in Biomedicine

L Santorelli, M Caterino, M Costanzo - International Journal of Molecular …, 2023 - mdpi.com
The technological advances of recent years have significantly enhanced medical
discoveries. In particular, biomedical research has been largely supported by the omics …