Circadian dysfunction in adipose tissue: chronotherapy in metabolic diseases
Simple Summary The circadian timing system is our bodies' built-in clock and controls our
physiology on a daily basis. This system helps us adapt to changes in our environment, such …
physiology on a daily basis. This system helps us adapt to changes in our environment, such …
[HTML][HTML] The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program
The tissues are the site of many important immunological reactions, yet how the immune
system is controlled at these sites remains opaque. Recent studies have identified Foxp3+ …
system is controlled at these sites remains opaque. Recent studies have identified Foxp3+ …
Transcriptional and hormonal control of adipose Treg heterogeneity and function
A Kallies, A Vasanthakumar - Immunological Reviews, 2024 - Wiley Online Library
Adipose tissue stores excess energy and produces a broad range of factors that regulate
multiple physiological processes including systemic energy homeostasis. Visceral adipose …
multiple physiological processes including systemic energy homeostasis. Visceral adipose …
Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet
AR Muñoz-Rojas, G Wang… - Proceedings of the …, 2024 - National Acad Sciences
Foxp3+ CD4+ regulatory T (Treg) cells found within tissues regulate local immunity,
inflammation, and homeostasis. Tregs in epididymal visceral adipose tissue (eVAT) are …
inflammation, and homeostasis. Tregs in epididymal visceral adipose tissue (eVAT) are …
Circadian mechanisms in adipose tissue bioenergetics and plasticity
The circadian clock plays an essential role in coordinating feeding and metabolic rhythms
with the light/dark cycle. Disruption of clocks is associated with increased adiposity and …
with the light/dark cycle. Disruption of clocks is associated with increased adiposity and …
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health
C Elkins, C Li - Immunological Reviews, 2024 - Wiley Online Library
Regulatory T cells (Tregs) within the visceral adipose tissue (VAT) play a crucial role in
controlling tissue inflammation and maintaining metabolic health. VAT Tregs display a …
controlling tissue inflammation and maintaining metabolic health. VAT Tregs display a …
Adipose tissue lipid metabolism: lipolysis
CH Cho, S Patel, P Rajbhandari - Current opinion in genetics & …, 2023 - Elsevier
Highlights•Molecular and cellular signals promoting and inhibiting lipolysis.•Transcriptional
control of lipolysis.•Adipose tissue microenvironment control of lipolysis.•Systemic effects of …
control of lipolysis.•Adipose tissue microenvironment control of lipolysis.•Systemic effects of …
Epigenetic regulation of human FOXP3+ Tregs: from homeostasis maintenance to pathogen defense
Y Yue, Y Ren, C Lu, P Li, G Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Regulatory T cells (Tregs), characterized by the expression of Forkhead Box P3 (FOXP3),
constitute a distinct subset of T cells crucial for immune regulation. Tregs can exert direct …
constitute a distinct subset of T cells crucial for immune regulation. Tregs can exert direct …
Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis
G Wang, AR Muñoz-Rojas, RG Spallanzani… - Immunity, 2024 - cell.com
Regulatory T (Treg) cells in epidydimal visceral adipose tissue (eVAT) of lean mice and
humans regulate metabolic homeostasis. We found that constitutive or punctual depletion of …
humans regulate metabolic homeostasis. We found that constitutive or punctual depletion of …
The danger theory of immunity revisited
The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue
stress, damage or infection has a decisive role in determining immune responses. Since …
stress, damage or infection has a decisive role in determining immune responses. Since …