Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Major depression is the commonest psychiatric disorder and in the US has the greatest
impact of all biomedical diseases on disability. Here we review evidence of the genetic …

BackgroundHigh levels of psychiatric morbidity in prisoners have been documented in many
countries, but it is not known whether rates of mental illness have been increasing over time …

A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …

Childhood trauma is a potent risk factor for developing depression in adulthood, particularly
in response to additional stress. We here summarize results from a series of clinical studies …

Depression is perhaps the most frequent cause of emotional suffering in later life and
significantly decreases quality of life in older adults. In recent years, the literature on late-life …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

Background The use of antidepressants in dementia accompanied by depressive symptoms
is widespread, but their clinical efficacy is uncertain. This review updates an earlier version …

The limited success of genetic studies of major depression has raised questions concerning
the definition of genetically relevant phenotypes. This paper presents strategies to improve …