This manuscript reviews recent advances in deterministic global optimization for Mixed-
Integer Nonlinear Programming (MINLP), as well as Constrained Derivative-Free …

Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

This manuscript introduces ANTIGONE, Algorithms for coNTinuous/Integer Global
Optimization of Nonlinear Equations, a general mixed-integer nonlinear global optimization …

Microorganisms evolved adaptive responses to survive stressful challenges in ever-
changing environments. Understanding the relationships between the physiological …

Background The estimation of parameter values for mathematical models of biological
systems is an optimization problem that is particularly challenging due to the nonlinearities …

Mixed-integer signomial optimization problems have broad applicability in engineering.
Extending the Global Mixed-Integer Quadratic Optimizer, GloMIQO (Misener, Floudas in J …

In this work, we present a systematic method for the optimal development of bioprocesses
that relies on the combined use of simulation packages and optimization tools. One of the …

Cells are natural factories that can adapt to changes in external conditions. Their adaptive
responses to specific stress situations are a result of evolution. In theory, many alternative …

The identification of the enzymatic profile that achieves a maximal production rate of a given
metabolite is an important problem in the biotechnological industry, especially if there is a …

Background Molecular interaction data at proteomic and genetic levels provide physical and
functional insights into a molecular biosystem and are helpful for the construction of pathway …