Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

Tumor microenvironment is considered nowadays as one of the main players in cancer
development and progression. Tumor microenvironment is highly complex and consists of …

Over half of colorectal cancers (CRCs) harbor TP53 missense mutations (mutp53). We show
that the most common mutp53 allele R248Q (p53 Q) exerts gain of function (GOF) and …

BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-
related protein produced in the periosteum and periodontal ligaments. Matricellular proteins …

Background Colorectal cancer is the third most frequently diagnosed cancer and the third
cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic …

The discovery of breast cancer associated plasma/serum biomarkers is important for early
diagnosis, disease mechanism elucidation, and determination of treatment strategy for the …

Simple Summary Cancers are common diseases that affect people of all ages worldwide.
For this reason, continuous attempts are being made to improve current therapeutic options …

Background Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS)
and xeroderma pigmentosum complementation group C (XPC) are three cancer‐prone …

Renal fibrogenesis is the common final pathway to all renal injuries that consequently leads
to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of …