Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

A wide range of human diseases, including cancer, has a striking age-dependent onset.
However, the molecular mechanisms that connect aging and cancer are just beginning to be …

The FOXO family of Forkhead transcription factors, FKHR (FOXO1), FKHR-L1 (FOXO3a) and
AFX (FOXO4), are regulated by the phosphoinositide-3-kinase–protein-kinase-B (PI3K …

Ras signaling plays an important role in erythropoiesis. Its function has been extensively
studied in erythroid and nonerythroid cell lines as well as in primary erythroblasts, but …

Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by
preventing apoptosis of erythroid progenitors. In addition to this proerythroid action, results …

Erythroid cells accumulate hemoglobin as they mature and as a result are highly prone to
oxidative damage. However, mechanisms of transcriptional control of antioxidant defense in …

Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the
discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has …

Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …

Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was
initially highlighted for its action on the hematopoietic system. Moreover, EPO is also …

Abstract Transferrin receptor 2 (TFR2) contributes to hepcidin regulation in the liver and
associates with erythropoietin receptor in erythroid cells. Nevertheless, TFR2 mutations …