Toxoplasma gondii is known to infect a considerable number of mammalian and avian
species and a substantial proportion of the world's human population. The parasite has an …

Appreciation of the entire biological impact of an individual protein can be hampered by its
original naming based on one function only. Tissue inhibitor of metalloproteinases-1 (TIMP …

Toxoplasma gondii is a widespread parasitic pathogen that infects over one third of the
global human population. The parasite invades and chronically persists in the central …

Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist
within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have …

Gamma-aminobutyric acid (GABA) is best known as an essential neurotransmitter in the
evolved central nervous system (CNS) of vertebrates. However, GABA antedates the …

Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-
established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this …

Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic
phase. However, genes involved in related in vivo processes are currently unknown. Here …

The blood–brain barrier (BBB) efficiently protects the central nervous system (CNS) from
infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable …

Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …

Background Understanding the mechanism behind sepsis-associated encephalopathy
(SAE) remains a formidable task. This study endeavors to shed light on the complex cellular …