Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

Mutations in several general pre-mRNA splicing factors have been linked to myelodysplastic
syndromes (MDSs) and solid tumors. These mutations have generally been assumed to …

The DNA damage response enables cells to cope with various stresses that threaten
genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 …

Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and
age-related diseases. Here, we performed high-throughput screening to identify compounds …

Abstract Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to
collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …