The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …

Apolipoprotein (apo) E4 sets the stage for neuropathology in Alzheimer's disease (AD) by
causing mitochondrial dysfunction and altering mitochondria-associated membranes …

Tumour cells have long been considered defective in mitochondrial respiration and mostly
dependent on glycolytic metabolism. However, this assumption is currently challenged by …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Heat shock protein 90 (HSP90) molecular chaperones are a family of ubiquitous proteins
participating in several cellular functions through the regulation of folding and/or assembly of …

Breast cancers are very heterogeneous tissues with several cell types and metabolic
pathways together sustaining the initiation and progression of disease and contributing to …

Metabolic reprogramming is an important issue in tumor biology. An unexpected inter-and
intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor …

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant that is widely distributed in
the natural environment. Cohort study showed that PFOA-producing workers displayed a …

Mitochondrial function is dependent on molecular chaperones, primarily due to their
necessity in the formation of respiratory complexes and clearance of misfolded proteins …