Antibiotic resistance is spreading rapidly around the world and seriously impeding efforts to
control microbial infections. Although nucleic acid testing is widely deployed for the …

A significant growth of research in nanofluidics is achieved over the past decade, but the
field is still facing considerable challenges toward the transition from the current physics …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Next generation sequencing (NGS) is revolutionizing all fields of biological research but it
fails to extract the full range of information associated with genetic material. Optical mapping …

Bacteria producing extended-spectrum β-lactamases (ESBLs) constitute a globally
increasing problem that contributes to treatment complications and elevated death rates …

Carbapenem-resistant Enterobacterales (CRE) is an increasing problem worldwide. Here,
we examined the clonal relatedness of 71 non-repetitive CRE isolates collected in a …

Bacterial plasmids are extensively involved in the rapid global spread of antibiotic
resistance. We here present an assay, based on optical DNA mapping of single plasmids in …

Stretching DNA in nanochannels is a useful tool for direct, visual studies of genomic DNA at
the single molecule level. To facilitate the study of the interaction of linear DNA with proteins …