Introduction Biological fluids are routine samples for diagnostic testing and monitoring.
Blood samples are typically measured because of their moderate invasive collection and …

Mass Spectrometry (MS) allows the analysis of proteins and peptides through a variety of
methods, such as Electrospray Ionization-Mass Spectrometry (ESI-MS) or Matrix-Assisted …

INTRODUCTION The choroid plexus is a secretory epithelial tissue of the central nervous
system (CNS) responsible for cerebrospinal fluid (CSF) production and functions as a barrier …

Parkinson's disease (PD) is a growing burden worldwide, and there is no reliable biomarker
used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients …

The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for
pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate …

Bottom-up proteomics provides peptide measurements and has been invaluable for moving
proteomics into large-scale analyses. Commonly, a single quantitative value is reported for …

Background There is a need for biomarkers to support an accurate diagnosis of Parkinson's
disease (PD). Cerebrospinal fluid (CSF) has been a successful biofluid for finding …

Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust
biomarkers are needed. Because protein structure reflects function, we tested whether …

The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …

Neurosecretory protein VGF (non-acronymic) belongs to the granin family of neuropeptides.
VGF and VGF-derived peptides have been repeatedly identified in well-powered and well …