[HTML][HTML] FoldX as protein engineering tool: better than random based approaches?
O Buß, J Rudat, K Ochsenreither - Computational and structural …, 2018 - Elsevier
Improving protein stability is an important goal for basic research as well as for clinical and
industrial applications but no commonly accepted and widely used strategy for efficient …
industrial applications but no commonly accepted and widely used strategy for efficient …
PremPS: Predicting the impact of missense mutations on protein stability
Y Chen, H Lu, N Zhang, Z Zhu, S Wang… - PLoS computational …, 2020 - journals.plos.org
Computational methods that predict protein stability changes induced by missense
mutations have made a lot of progress over the past decades. Most of the available methods …
mutations have made a lot of progress over the past decades. Most of the available methods …
A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases
Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …
found in the brain and plays a significant role in developing the central nervous system …
Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disorder, with a
significant social and economic burden. ALS remains incurable, and the only drugs …
significant social and economic burden. ALS remains incurable, and the only drugs …
Targeted protein degraders march towards the clinic for neurodegenerative diseases
Protein degraders are emerging as potent therapeutic tools to address neurological
disorders and many complex diseases. It offered several key advantages, including the …
disorders and many complex diseases. It offered several key advantages, including the …
Combining structural aggregation propensity and stability predictions to redesign protein solubility
The aggregation propensity of each particular protein seems to be shaped by evolution
according to its natural abundance in the cell. The production and downstream processing …
according to its natural abundance in the cell. The production and downstream processing …
Identifying the molecular drivers of ALS-implicated missense mutations
S Portelli, A Albanaz, DEV Pires… - Journal of Medical …, 2023 - jmg.bmj.com
Background Amyotrophic lateral sclerosis (ALS) is a progressively fatal, neurodegenerative
disease associated with both motor and non-motor symptoms, including frontotemporal …
disease associated with both motor and non-motor symptoms, including frontotemporal …
Impact of amino acid substitution in the kinase domain of Bruton tyrosine kinase and its association with X-linked agammaglobulinemia
X-linked agammaglobulinemia (XLA) is a rare disease that affects the immune system,
characterized by a serial development of bacterial infection from the onset of infantile age …
characterized by a serial development of bacterial infection from the onset of infantile age …
Insights into the conserved regulatory mechanisms of human and yeast aging
Aging represents a significant biological process having strong associations with cancer,
diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive …
diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive …
Expedition into taurine biology: structural insights and therapeutic perspective of taurine in neurodegenerative diseases
Neurodegenerative diseases (NDs) are characterized by the accumulation of misfolded
proteins. The hallmarks of protein aggregation in NDs proceed with impairment in the …
proteins. The hallmarks of protein aggregation in NDs proceed with impairment in the …