The receptor tyrosine kinase (RTK) gene family, involved primarily in cell growth and
differentiation, comprises proteins with a common enzymatic tyrosine kinase intracellular …

Embryonic terminal patterning and moulting are critical developmental processes in insects.
In Drosophila and Tribolium both of these processes are regulated by the Torso‐activation …

In the course of their evolution, the genomes of vertebrates have been subject to several
events of whole-genome duplication (WGD): two rounds at the base of the vertebrates, a …

The thought of “Protein phosphorylation” always draws attention to Ser/Thr kinases or
phosphatases as they were discovered prior to the mechanism of Tyr phosphorylation. Tyr …

Tumor-associated inflammation has been recently recognized as one of the hallmarks of
cancers. In particular, inflammatory cytokines secreted in the tumor microenvironment have …

Ligand-induced internalisation and subsequent downregulation of receptor tyrosine kinases
(RTKs) serve to determine biological outputs of their signalling. Intrinsically kinase-deficient …